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KMID : 0376419890130020125
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Chonbuk University Medical Journal
1989 Volume.13 No. 2 p.125 ~ p.133
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The Effect of pH on Mast Cell Degranulation Induced by Compoung 48/80
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Cho Myung-Ho
Park Byoung-Keon
Ko Byoung-Moon
Jun Byoung-Duek
Lee Moo-Sam
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Abstract
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This study was performed to investigate the effects of pH on the degranulation of mesenteric and peritoneal mast cells induced by compound 48/80 in vivo and in vitro, and to determine the optimal dosage of compound 48/80 for the mast cell degranulation in various pH.
Results were as following
1. In vivo study using mesenteric mast cells : the effect of compound 48/80 ( lpg/ml) on mast cells was markedly increased in pH 7.8.
2 . In vitro study using peritoneal mast cells : the onset time :)f degranulation of mast cell induced by compound 48/80(0.33l1g/ml) was shorter in pH 7. 2 :.nd 7.8 than those in pH 5. 5,
6. 4 and 8. 5.
Above results suggested that response of mast cell to compourd 48/80 was rapidly degranulated in pH 7.2 and pH 7.8.
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KEYWORD
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Mast cell, Degranulation, pH, Compoung 48/80
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